MOTS-c vs NAD-plus
Dosing, half-life, mechanism, benefits, and safety — side by side.
MOTS-c
ResearchMitochondrial-derived peptide for metabolic health and exercise performance
Half-Life
4 hours
Route
SC
Dose
5-10mg 3x weekly
MW
2174.61 Da
NAD-plus
ResearchEssential coenzyme for cellular energy and DNA repair
Half-Life
Short
Route
IV/SC/Oral
Dose
100-500mg daily
MW
663.43 Da
Quick Reference
| MOTS-c | NAD-plus | |
|---|---|---|
| Category | N/A | N/A |
| Route | SC | IV/SC/Oral |
| Typical Dose | 5-10mg 3x weekly | 100-500mg daily |
| Frequency | 3x weekly | daily |
| FDA Approved | No | No |
| WADA Status | Not banned | Not banned |
⏱ Pharmacokinetics
| MOTS-c | NAD-plus | |
|---|---|---|
| Half-Life | 4 hours | Short |
| Research Status | Research compound - Mitochondrial peptide | Supplement - Cellular cofactor |
| CAS Number | 1627580-64-6 | 53-84-9 |
Molecular
| MOTS-c | NAD-plus | |
|---|---|---|
| Molecular Weight | 2174.61 | 663.43 |
| Molecular Formula | C101H152N28O22S2 | C21H27N7O14P2 |
| Sequence Length | 16 aa | 277 aa |
| Mechanism | Mitochondrial-derived peptide that regulates metabolic homeostasis | Cellular energy metabolism and DNA repair |
Key Benefits
| MOTS-c | NAD-plus | |
|---|---|---|
| Benefits | Metabolic Homeostasis: Prevents insulin resistance, obesity; Muscle Protection: Reduces myostatin signaling; Metabolic health; Longevity support; Energy boost; Cellular health; Anti-aging effects; Exercise mimetic | Enhanced cellular energy; DNA repair support; Anti-aging effects; Metabolic optimization; Neuroprotection; Energy boost; Cellular health; Anti-aging support |
Safety & Warnings
| MOTS-c | NAD-plus | |
|---|---|---|
| Safety Note | Research compound only. Limited human safety data available. | Generally considered safe as a supplement. Consult healthcare provider for appropriate dosing. |
| Side Effects | Headache; Rare systemic effects; Mild nausea; Fatigue | Flushing; Nausea; Headache; Abdominal cramps; Rare allergic reactions |
| Athlete Warning | 🛑 WADA BANNED - Prohibited in competitive sports as immune modulating peptide | Not WADA banned - cellular metabolism compound safe for competitive athletes |
Which should you choose?
Both MOTS-c and NAD-plus have meaningful research support. The right choice depends on your specific goals, tolerance, and whether an FDA-approved option fits your needs.
MOTS-c vs NAD-plus — FAQ
Which has a longer half-life: MOTS-c or NAD-plus?
MOTS-c has a half-life of ~4 hours while NAD-plus has a half-life of ~Short. A longer half-life generally means less frequent dosing and more stable levels.
Can I stack MOTS-c and NAD-plus together?
Whether MOTS-c and NAD-plus can be stacked depends on their mechanisms and receptor targets. Use the stack compatibility checker to analyze synergies and conflicts before combining any peptides.
Which is better: MOTS-c or NAD-plus?
There is no universal "better" peptide — it depends on your goal. MOTS-c is Mitochondrial-derived peptide that regulates metabolic homeostasis. NAD-plus is Cellular energy metabolism and DNA repair. Choose based on your primary goal and research profile.
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