Ipamorelin vs Sermorelin
Dosing, half-life, mechanism, benefits, and safety — side by side.
Ipamorelin
ResearchSelective growth hormone releasing peptide with minimal side effects
Half-Life
~2 hours
Route
SC
Dose
100-300 mcg 1-3x/day
MW
711.85 Da
Sermorelin
ResearchGHRH analog stimulating natural growth hormone production
Half-Life
10-20 minutes
Route
SC
Dose
200-500 mcg Daily
MW
3357.88 Da
Quick Reference
| Ipamorelin | Sermorelin | |
|---|---|---|
| Category | N/A | N/A |
| Route | SC | SC |
| Typical Dose | 100-300 mcg 1-3x/day | 200-500 mcg Daily |
| Frequency | N/A | Daily |
| FDA Approved | No | No |
| WADA Status | Banned | Banned |
⏱ Pharmacokinetics
| Ipamorelin | Sermorelin | |
|---|---|---|
| Half-Life | ~2 hours | 10-20 minutes |
| Research Status | Research compound - Growth hormone agonist | FDA approved |
| CAS Number | 170851-70-4 | 86168-78-7 |
Molecular
| Ipamorelin | Sermorelin | |
|---|---|---|
| Molecular Weight | 711.85 | 3357.88 |
| Molecular Formula | C38H49N9O5 | C149H246N44O42S |
| Sequence Length | 28 aa | 216 aa |
| Mechanism | Selective GH secretagogue with minimal side effects | GHRH analogue for pulsatile GH release |
Key Benefits
| Ipamorelin | Sermorelin | |
|---|---|---|
| Benefits | Increases lean muscle mass; Reduces body fat; Improves sleep; Collagen production.; Muscle protein synthesis; Improved sleep quality; Collagen turnover support; Clean GH stimulation | Natural GH stimulation; Improved sleep; Recovery enhancement; Anti-aging effects; Body composition; FDA approved; Increases natural GH production; Improves sleep |
Safety & Warnings
| Ipamorelin | Sermorelin | |
|---|---|---|
| Safety Note | Research compound only. Forbidden in sport. May cause temporary flushing, mild head pressure, or minor water retention. | FDA approved for growth hormone deficiency. Well-established safety profile. |
| Side Effects | Does NOT stimulate ACTH or cortisol (unique selectivity profile); No ACTH/cortisol release; Injection site reactions; Overall AE incidence; Mild dizziness; Rare local irritation; Headache; Mild side effect | Interaction; Interaction; Antibody formation; Dizziness, urticaria; Injection site reactions; Headache; Flushing; Generally well-tolerated |
| Athlete Warning | 🛑 WADA BANNED - Prohibited in competitive sports as selective growth hormone releasing peptide | 🛑 WADA BANNED - Prohibited in competitive sports as growth hormone releasing agent |
Which should you choose?
Sermorelin has a longer half-life (~10-20 minutes) than Ipamorelin (~~2 hours), which can mean less frequent dosing.
Ipamorelin vs Sermorelin — FAQ
Which has a longer half-life: Ipamorelin or Sermorelin?
Ipamorelin has a half-life of ~~2 hours while Sermorelin has a half-life of ~10-20 minutes. A longer half-life generally means less frequent dosing and more stable levels.
Can I stack Ipamorelin and Sermorelin together?
Whether Ipamorelin and Sermorelin can be stacked depends on their mechanisms and receptor targets. Use the stack compatibility checker to analyze synergies and conflicts before combining any peptides.
Which is better: Ipamorelin or Sermorelin?
There is no universal "better" peptide — it depends on your goal. Ipamorelin is Selective GH secretagogue with minimal side effects. Sermorelin is GHRH analogue for pulsatile GH release. Choose based on your primary goal and research profile.
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