Selank
Anxiolytic peptide for stress reduction and immune modulation
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Overview
Selank is a synthetic peptide developed in Russia that combines anti-anxiety effects with cognitive enhancement — without the sedation or addiction risk of traditional anti-anxiety medications. **What makes it unique?** Selank is based on tuftsin, a natural immune-regulating peptide in your body, with an added sequence to make it more stable. This gives it a dual action: it calms anxiety while sharpening mental function. **What the research shows:** • Reduces anxiety without causing drowsiness or impairment • Increases BDNF (brain-derived neurotrophic factor) — a protein crucial for learning and memory • May help with focus, memory consolidation, and mental clarity • Shows immune-modulating properties • Can reduce symptoms of alcohol withdrawal **How it works:** Selank influences multiple neurotransmitter systems including serotonin and dopamine, but in a balancing way rather than overwhelming them like some pharmaceuticals. **Typical use:** Usually administered as a nasal spray for direct brain delivery, though injectable forms exist. **Important to know:** Selank is approved in Russia for anxiety and cognitive disorders but is not FDA-approved in the United States. Research is promising but primarily from Russian institutions. --- **Sources:** Seredenin SB, et al. (2019) Bulletin of Experimental Biology and Medicine. DOI:10.1007/s10517-019-04588-9 | Zozulya AA, et al. (2008) Regulatory Peptides

Quick Facts
Formula:C33H57N11O9
Molecular Weight:751.87
Sequence:Thr-Lys-Pro-Arg-Pro-Gly-Pro
Mechanism:Anxiolytic peptide with cognitive enhancement properties
⚠️ Safety Information
Research compound only in most countries. Limited long-term safety data available.
Research Citations
Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.
Povarov IS, Kondratenko RV, Derevyagin VI, Myasoedov NF, Skrebitsky VG (2017)
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
Konstantinopolsky MA, Chernyakova IV, Kolik LG (2022)
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.
Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD (2019)
Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.
Fomenko EV, Bobyntsev II, Ivanov AV, Belykh AE, Andreeva LA, Myasoedov NF (2019)
The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.
Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, Fedorovich MN, Aleksandrovna AL (2021)
+ 20 more citations