Selank

Anxiolytic peptide for stress reduction and immune modulation

20 views

Overview

Selank is a synthetic peptide developed in Russia that combines anti-anxiety effects with cognitive enhancement — without the sedation or addiction risk of traditional anti-anxiety medications. **What makes it unique?** Selank is based on tuftsin, a natural immune-regulating peptide in your body, with an added sequence to make it more stable. This gives it a dual action: it calms anxiety while sharpening mental function. **What the research shows:** • Reduces anxiety without causing drowsiness or impairment • Increases BDNF (brain-derived neurotrophic factor) — a protein crucial for learning and memory • May help with focus, memory consolidation, and mental clarity • Shows immune-modulating properties • Can reduce symptoms of alcohol withdrawal **How it works:** Selank influences multiple neurotransmitter systems including serotonin and dopamine, but in a balancing way rather than overwhelming them like some pharmaceuticals. **Typical use:** Usually administered as a nasal spray for direct brain delivery, though injectable forms exist. **Important to know:** Selank is approved in Russia for anxiety and cognitive disorders but is not FDA-approved in the United States. Research is promising but primarily from Russian institutions. --- **Sources:** Seredenin SB, et al. (2019) Bulletin of Experimental Biology and Medicine. DOI:10.1007/s10517-019-04588-9 | Zozulya AA, et al. (2008) Regulatory Peptides

Selank peptide molecular structure diagram for research - Anxiolytic peptide with cognitive enhancement properties

Quick Facts

Formula:C33H57N11O9
Molecular Weight:751.87
Sequence:Thr-Lys-Pro-Arg-Pro-Gly-Pro
Mechanism:Anxiolytic peptide with cognitive enhancement properties

⚠️ Safety Information

Research compound only in most countries. Limited long-term safety data available.

Research Citations

Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

Povarov IS, Kondratenko RV, Derevyagin VI, Myasoedov NF, Skrebitsky VG (2017)

Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.

Fomenko EV, Bobyntsev II, Ivanov AV, Belykh AE, Andreeva LA, Myasoedov NF (2019)

The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.

Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, Fedorovich MN, Aleksandrovna AL (2021)

+ 20 more citations